Search results for "Transcorneal delivery"

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Mucoadhesive PEGylated inulin-based self-assembling nanoparticles: In vitro and ex vivo transcorneal permeation enhancement of corticosteroids

2019

Abstract As transcorneal drug delivery is still a challenge, the scope of the present study was to prepare useful nanosystems able to enhance transcorneal permeation/penetration of drugs. Moreover, this work aims to evaluate the effectiveness of inulin-based nanosystems in the specific field of ocular drug delivery and the effect of PEG chains to promote mucoadhesion, stability and transcorneal penetration/permeation enhancer effect of self-assembling nanoparticles in vitro (transwell systems and HCE) and ex vivo (Franz cells and bovine cornea). In particular, inulin was chosen as the starting natural polysaccharide polymer to design a novel amphiphilic derivative named INU-EDA-RA-PEG capab…

Polyethylene glycolInulin Self-assembling nanoparticles Transcorneal delivery Retinoic acid Polyethylene glycolTranscorneal deliveryInulinInulinSelf-assembling nanoparticlesPharmaceutical ScienceNanoparticle02 engineering and technologyPenetration (firestop)Permeation021001 nanoscience & nanotechnology030226 pharmacology & pharmacy03 medical and health scienceschemistry.chemical_compound0302 clinical medicinechemistrySettore CHIM/09 - Farmaceutico Tecnologico ApplicativoDrug deliveryAmphiphilePEG ratioRetinoic acidMucoadhesionBiophysics0210 nano-technologyJournal of Drug Delivery Science and Technology

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